Talk:CAR T cell

Wiki Education Foundation-supported course assignment

This article was the subject of a Wiki Education Foundation-supported course assignment, between 1 March 2021 and 28 March 2021. Further details are available on the course page. Student editor(s): Llamabread. Peer reviewers: Patellaton.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 17:28, 16 January 2022 (UTC)

Biological engineering

Biological engineering is very much like hacking a large computer program where only few of the rules and structures are understood. I would like more people in the computer world to become more interested in these subjects as I feel our thinking has become too limited. — Preceding unsigned comment added by Mxpule (talk • contribs) 00:05, 20 March 2005‎

Work in progress — Preceding unsigned comment added by Mxpule (talk • contribs) 21:49, 13 April 2011 (UTC)

Survey article by New England Journal of Medicine

I'm not necessarily gifted with the patience or ability to craft and edit large strings of encyclopedic text, so all I'll do is include this survey article, released recently by the New England Journal of Medicine, here. It might be nice to go through this one and see if any good information can be added to this article. — Preceding unsigned comment added by 68.55.22.150 (talk) 19:43, 11 August 2011 (UTC)

Update clinical trial section

Hey guys, time to update the "clinical trial" part with the recently published results of Dr June's lab: http://www.nejm.org/doi/full/10.1056/NEJMoa1103849 and http://stm.sciencemag.org/cgi/pmidlookup?view=short&pmid=21832238 Will help if I find time during my research. Get excited, this is big! Ulalume (talk) 15:24, 28 September 2011 (UTC)

CAR Use in Clinical Trials

Chimeric Antigen Receptors Modified T Cells cor Cancer Therapy This review article contains useful information on recent clinical trials that have used CAR to treat cancer. It would be useful to include these in this article to reflect recent advances in CAR based treatment. Table 1 and Table 2 of this article lists the published results of clinical trials using CAR to treat hematologic malignancies and solid tumors.Jdteruya (talk) 21:49, 12 February 2016 (UTC)

What types of cancers are not appropriate targets for CAR-T?

The article doesn't currently list types of cancers which are or are not suitable targets for the CAR-T technology. David Spector (talk) 23:22, 1 April 2017 (UTC)

Propose rename to CAR-T or Chimeric antigen receptor T cell

The only application of CAR seems to be in CAR-T cells, and most of this article seems to be about CAR-T ( used in a type of adoptive cell therapy ) so perhaps we should rename this page (and have CAR as a section - which could maybe later be split out) ? - Rod57 (talk) 09:53, 16 June 2017 (UTC)

@Rod57: I do not know anything about this topic so I am not sure. However, I did a search for "Chimeric antigen receptor" and all the results I checked on the front page were talking about CAR-T cells and not CAR generally. I say that if you are willing to clean up the lead a little to make it clear that the article is about the T-cell and not the concept of the receptor outside the context of the T-cell, then do the move. Blue Rasberry (talk) 14:00, 16 June 2017 (UTC)

article structure

This is getting a bit wild. Seems to me that this should be structured per WP:MCBMOS. Objections? Jytdog (talk) 21:36, 31 August 2017 (UTC)

Hyphens: “CAR T cell” vs “CAR-T cell”

In the article, both “CAR-T cell” and “CAR T cell” are used. Unless I’m mistaken, “chimeric antigen receptor-T” doesn’t mean anything, so “CAR-T cell” is absurd. The National Cancer Institute writes “CAR T cell” and “CAR T-cell therapy”, which seems consistent with ordinary English usage. Shouldn’t Wikipedia do the same? palpalpalpal (talk) 19:14, 6 October 2019 (UTC)

Article Update

Hi everyone - as part of a UCSF medical school course, I am working to improve this article. Am planning to add information related to the clinical use of CAR T cells. Hopefully this will make the article more useful to a broader audience of patients, clinical providers, and the general public. My overall goal is to make this article more useful as an overview page for a category of drugs (such as pages for Beta blocker and Monoclonal antibody). Am planning to add/rename the headings per the outline of work below. Looking forward to working with other editors to help improve this page!

History Add new dedicated section incorporating existing "Clinical studies and FDA approvals" section and "Evolution of CAR Design" section text. Where possible will switch primary source reference to trusted secondary sources, except where primary articles are of particular historic importance. In that case will include references to secondary sources as well which discuss that importance.

Chimeric Antigen Receptor Structure Condense existing section, with a focus on removing references to primary scientific articles, especially early phase pre-clinical work, and replacing with trusted secondary sources such as review articles and published clinical guidelines.

Clinical Applications Move text from current Cancer Treatment section here, as well as describe applications of CAR T cells in non-cancer settings with additional subheadings, such as Autoimmune disease and Infectious disease. Add a table of specific CAR T target antigens and their associated disease setting.

Production Leave existing discussion largely as is. Will expand discussion of autologous vs allogeneic cell sources, and methods of integrating CAR DNA sequence.

Safety Move existing safety discussion to its own heading, and add subheadings for major safety concerns and current clinical guidelines for Cytokine Release Syndrome and Immune Cell Effector Related Neurotoxicity. Will add subheading for Control Mechanisms and incorporate existing text, while reworking references to reduce use of primary sources.

FDA Approved CAR T Cells Add a table for the currently four approved FDA CAR T cells which can be easily expanded to accommodate future examples. Similar to table found in Monoclonal antibody therapy article.

Economics Add new section describing debate and concerns around the cost of CAR T therapies and new payment models developed.

Llamabread (talk) 05:25, 5 March 2021 (UTC)

Peer review

Hi Llamabread!

Thanks for the chance to review your work for our elective. See my responses to your proposed work plan and progress thus far below:

History Add new dedicated section incorporating existing "Clinical studies and FDA approvals" section and "Evolution of CAR Design" section text. Where possible will switch primary source reference to trusted secondary sources, except where primary articles are of particular historic importance. In that case will include references to secondary sources as well which discuss that importance.

- The text added under the new History section adds to the lay person's understanding of relevant background. This is a great contribution to the page.

Chimeric Antigen Receptor Structure Condense existing section, with a focus on removing references to primary scientific articles, especially early phase pre-clinical work, and replacing with trusted secondary sources such as review articles and published clinical guidelines.

Clinical Applications Move text from current Cancer Treatment section here, as well as describe applications of CAR T cells in non-cancer settings with additional subheadings, such as Autoimmune disease and Infectious disease. Add a table of specific CAR T target antigens and their associated disease setting.

Production Leave existing discussion largely as is. Will expand discussion of autologous vs allogeneic cell sources, and methods of integrating CAR DNA sequence.

- The existing production section reads well and provides a succinct summary. Agree to leave as is.

Safety Move existing safety discussion to its own heading, and add subheadings for major safety concerns and current clinical guidelines for Cytokine Release Syndrome and Immune Cell Effector Related Neurotoxicity. Will add subheading for Control Mechanisms and incorporate existing text, while reworking references to reduce use of primary sources.

FDA Approved CAR T Cells Add a table for the currently four approved FDA CAR T cells which can be easily expanded to accommodate future examples. Similar to table found in Monoclonal antibody therapy article.

- I really like this addition. The table reads easily and is a great quick reference for those skimming the page. Good idea to base this off the table found in the monoclonal antibody therapy page.

Economics Add new section describing debate and concerns around the cost of CAR T therapies and new payment models developed.

- Will be interesting to see these additions since it will address controversial topic

General thoughts

- Is the language both scientifically/clinically useful but also understandable to the general Wikipedia reader? I think the additions you have made so far read easily. I do think given the complexity of your article topic, it is tricky to avoid all medical/scientific jargon, but you strike a nice balance.

- Addition of research directions will be interesting for patients and providers alike

- Page organization: I thought the edits you made in reorganizing the page made the article read smoothly. It'd be great to hear thoughts of our fellow Wikipedians who are actively editing the page - can you talk us through the reasoning behind your organizational edits?

- Great work so far! Looking forward to seeing the final edits you make this week. — Preceding unsigned comment added by Patellaton (talk • contribs) 06:10, 22 March 2021 (UTC)

Thank you Patellaton for your review! Encouraging to hear your positive thoughts on the review. I've gone ahead and added an economics section as well at the end of the article along the lines of your suggestions. Llamabread (talk) 22:15, 24 March 2021 (UTC)

Clarify which treaments are autologous and which are allogeneic

I think all the 5 FDA approved treatments are autologous (using the patient's own T-cells), but there is research and trials into allogenic (off-the-shelf) treatments. Could we note this somehow, maybe in the table for FDA approvals ? - Rod57 (talk) 20:20, 17 October 2021 (UTC)

References

Please add info on 2022 viral vector-less CRISPR tech to Research directions

I could be wrong about this, but I think it's well worth at least a brief mention under section "Research directions" now. The info could contain some brief info on this study, included in 2022 in science (August) like so:

Researchers report the development of a highly effective CRISPR-Cas9 genome editing method without expensive viral vectors, enabling e.g. novel anti-cancer CAR-T cell therapies.

From the news report (see the refs):

In the study, researchers used the new DNA template to generate more than a billion CAR-T cells that target multiple myeloma. CAR-T cells are immune T cells genetically modified to effectively fight specific cells or cancers. With the new single-stranded, Cas9 directed templates, approximately half of all T cells gained the new gene and, as a result, were converted to CAR-T cells.

"We knew that targeting the DNA templates to a specific location in the genome, called the TRAC site, would improve the anti-tumor potency of CAR-T cells," says Justin Eyquem, Ph.D., a co-author of the new paper, assistant professor of medicine in the Division of Hematology and Oncology at UCSF, and affiliate investigator at Gladstone. "This new non-viral approach enables us to achieve that targeting much more efficiently, which will accelerate the development of the next generation of CAR-T cell therapies."

If you don't think the method/approach and/or study is currently due to get mentioned there, please briefly explain why.

References

Prototyperspective (talk) 12:35, 8 November 2022 (UTC)

Wiki Education assignment: ENGW3307 Adv Writing for the Sciences 11520

This article was the subject of a Wiki Education Foundation-supported course assignment, between 6 September 2023 and 13 December 2023. Further details are available on the course page. Student editor(s): Fizzlepie (article contribs).

— Assignment last updated by Fizzlepie (talk) 17:07, 27 October 2023 (UTC)

Hello everyone,

As part of the Advance Writing for the Sciences course, I will be working to improve the worldwide view of this article by modifying the FDA-approved CAR T cell therapies section.

Plan:

I'm planning to rename the heading to "CAR T Cell Therapies with Regulatory Approval". For the table, I'm planning to add an "Approved Agency" column to indicate which government agencies have approved the product for use. As a result, the approval date column will have multiple dates added. I intend on adding a reference to indicate which agency each date corresponds to. I will add every drug label link I can find from the other non-FDA agencies and rename the links to a more agency-specific link name (ex: "FDA link"). For the indications column, I will add references indicate the agencies each disease and line of therapy has been given approval for.

If I have any extra time, I will look to add citations to any "citation needed" tags. Fizzlepie (talk) 14:51, 16 November 2023 (UTC)