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O'Fallon may refer to:
- James O'Fallon (bef 1756–1786), Irish Roman Catholic clergyman
- John O'Fallon (1786–1865), American businessman, philanthropist, and military officer
- Peter O'Fallon, American television director
- O'Fallon, Illinois, United States
- O'Fallon Township, St. Clair County, Illinois, United States
- O'Fallon, Missouri, United States
- O'Fallon, St. Louis, a neighborhood in the city of St. Louis, Missouri, United States
| disambiguation page lists articles associated with the title O'Fallon.
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