Talk:Phenethylamine

This is the talk page for discussing improvements to the Phenethylamine article.
This is not a forum for general discussion of the article's subject.

Put new text under old text. Click here to start a new topic.
New to Wikipedia? Welcome! Learn to edit; get help.

Article policies

Find medical sources: Source guidelines · PubMed · Cochrane · DOAJ · Gale · OpenMD · ScienceDirect · Springer · Trip · Wiley · TWL

Archives: Index, 1: 90 days

Pharmacology High‑importance

	This article is within the scope of WikiProject Pharmacology, a collaborative effort to improve the coverage of Pharmacology on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks.PharmacologyWikipedia:WikiProject PharmacologyTemplate:WikiProject Pharmacologypharmacology articles
High	This article has been rated as High-importance on the project's importance scale.

Medicine Mid‑importance

	Medicine portal This article is within the scope of WikiProject Medicine, which recommends that medicine-related articles follow the Manual of Style for medicine-related articles and that biomedical information in any article use high-quality medical sources. Please visit the project page for details or ask questions at Wikipedia talk:WikiProject Medicine.MedicineWikipedia:WikiProject MedicineTemplate:WikiProject Medicinemedicine articles
Mid	This article has been rated as Mid-importance on the project's importance scale.

Chemicals Mid‑importance

	This article is within the scope of WikiProject Chemicals, a daughter project of WikiProject Chemistry, which aims to improve Wikipedia's coverage of chemicals. To participate, help improve this article or visit the project page for details on the project.ChemicalsWikipedia:WikiProject ChemicalsTemplate:WikiProject Chemicalschemicals articles
Mid	This article has been rated as Mid-importance on the project's importance scale.

Ideal sources for Wikipedia's health content are defined in the guideline Wikipedia:Identifying reliable sources (medicine) and are typically review articles. Here are links to possibly useful sources of information about Phenethylamine.

PubMed provides review articles from the past five years (limit to free review articles)
The TRIP database provides clinical publications about evidence-based medicine.
Other potential sources include: Centre for Reviews and Dissemination and CDC

Legal status UK[edit]

It must be a mistake that the legal status of phenethylamine is "Class A" in the UK. Or is chocolate now illegal in the UK?!?
If it would be true, then the next step would be a ban on phenylalanine, because of being a precursor of phenethylamine -> phenylalanine is an essential amino acid => no phenylalanine, no human life possible

Regards, Stefan --Stefan Bach7777 (talk) 21:05, 16 April 2015 (UTC)[reply]

Drugs controlled by the UK Misuse of Drugs Act#Class A drugs says compounds "structurally derived from phenethylamine" are banned but it doesn't say anything about phenethylamine itself. I'll change this. Sizeofint (talk) 23:44, 16 April 2015 (UTC)[reply]

Legal Status in NZ[edit]

Hi guys,

There seems to be some issues with the footnote for whether this compound is legal in NZ. Firstly, the reference isn't the correct way of referencing legislation or schedules within. Secondly, the reference may be out of date or incorrect as a search of that piece of legislation reveals no mention of it anywhere. Could someone please look into this? — Preceding unsigned comment added by ClubmanGT (talk • contribs) 22:11, 15 April 2016 (UTC)[reply]

Phenethylamine monographs[edit]

There is a LOT of content from these sources that needs to be added to the article. Seppi333 (Insert 2¢) 21:32, 20 September 2016 (UTC)[reply]

Phenethylamine monographs

Hazardous Substances Data Bank: ^[1]
PubChem: ^[2]
Human Metabolome Database: ^[3]
- HMDB phenylacetic acid entry (PEA's primary metabolite from MAO-B+MAO-A-mediated oxidative deamination)

References

^ 2-PHENYLETHYLAMINE. Hazardous Substances Data Bank. Retrieved 20 September 2016. {{cite encyclopedia}}: |work= ignored (help)
^ Phenethylamine. PubChem Compound. Retrieved 20 September 2016. {{cite encyclopedia}}: |work= ignored (help)
^ Phenylethylamine. Human Metabolome Database. 11 February 2016. Retrieved 20 September 2016. {{cite encyclopedia}}: |work= ignored (help)

New review to add[edit]

^[1] - probably worth adding content from tables 3+4 and the article text. Seppi333 (Insert 2¢) 19:57, 30 January 2017 (UTC)[reply]

References

^ Khan MZ, Nawaz W (October 2016). "The emerging roles of human trace amines and human trace amine-associated receptors (hTAARs) in central nervous system". Biomed. Pharmacother. 83: 439–449. doi:10.1016/j.biopha.2016.07.002. PMID 27424325.

makes you feel like you're falling in love?[edit]

Could someone add something about the research about this chemical in chocolate and it allegedly causing a feeling of falling in love? — Preceding unsigned comment added by Skysong263 (talk • contribs) 23:36, 14 July 2019 (UTC)[reply]

Do you have some WP:RS in mind? Wikipedia is the encyclopedia anyone can edit, so feel free to write and cite. DMacks (talk) 02:10, 15 July 2019 (UTC)[reply]

chocolate doesn't have much to do with phenethylamine tbh, but phenethylamine itself is VERY wired in the brain pathways mainly in love and stuff like that. phenethylamine is released in massive amounts when your in love and is the main reason some often feel high off love. Doxylamine (talk) 04:19, 31 October 2023 (UTC)[reply]

I couldn't find anything supporting that PEA is released in situations where we would call "being in love" or other social situations except for physical sexual activity but there's other compounds from dopamine to epinephrine there. Eyes dilating from looking at someone sexually attractive has been attributed to Epinephrine. Some articles have claimed Oxytocin is one of the main reason people feel good from feeling in-love and there is some research supporting Oxytocin release in social situations outside of sexual physical activity. But it's likely not one single chemical. But either way couldn't find anything scientific in regards to PEA release to support the claim of it's relation to feeling in love. Gettinglit (talk) 22:16, 11 November 2023 (UTC)[reply]

i would say the 'love' feeling phenethylamine produces is much similar to what meth or coke does to people (making them horny or lovey) but a thousand fold at high doses and very very different despite similarity. I mainly feel phenethylamine in love when i first meet someone i really like (not as much once im used to them) and i get the exact same feeling phenethylamine gives me mixed with oxytocin and some other stuff. The love feeling is definitely a mix and not just pea but i would say its mainly phenethylamine, oxytocin, and serotonin. But I don't have any direct evidence except personal first-hand experiences but that doesn't count much for shit unless i have a study; but i'm very willing to bet pea is one of the main love hormones, like, 80-90% sure. 159.118.198.249 (talk) 20:12, 12 November 2023 (UTC)[reply]

Is this a contradiction?[edit]

In the article's lede it states "in orally ingested phenethylamine, a significant amount is metabolized in the small intestine by monoamine oxidase B (MAO-B)". However, further down in the "Detection in bodily fluids" section, it states "β-PEA would not be deaminated in the gut as it is a selective substrate for MAO-B, which is not found in the gut". These two statements are seemingly contradictory as the first one says it's metabolized in the small intestine (which is part of "the gut," is it not?) and the second one says it's not. Wondering if someone with more pharmacokinetics knowledge can clear this up. Lumberjane Lilly (talk) 14:07, 16 September 2021 (UTC)[reply]

[TOXNET_PEA-1] 2-PHENYLETHYLAMINE. Hazardous Substances Data Bank. Retrieved 20 September 2016. {{cite encyclopedia}}: |work= ignored (help)

[PubChem_PEA-2] Phenethylamine. PubChem Compound. Retrieved 20 September 2016. {{cite encyclopedia}}: |work= ignored (help)

[HMDB_PEA-3] Phenylethylamine. Human Metabolome Database. 11 February 2016. Retrieved 20 September 2016. {{cite encyclopedia}}: |work= ignored (help)

[Human_trace_amines_and_hTAARs_October_2016_review-4] Khan MZ, Nawaz W (October 2016). "The emerging roles of human trace amines and human trace amine-associated receptors (hTAARs) in central nervous system". Biomed. Pharmacother. 83: 439–449. doi:10.1016/j.biopha.2016.07.002. PMID 27424325.

[1]

[2]

[3]

[1]