Talk:Isotretinoin

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Confusing wording in the lead paragraphs[edit]

"Women taking isotretinoin must not get pregnant during and for 1 month after the discontinuation of isotretinoin therapy."

So, is it the case that a woman taking the medication must not get pregnant during the discontinuation of the therapy plus up to one (see MOS for numbers, BTW) month after said discontinuation process has been completed? Or, is it instead the case that she must not get pregnant during the therapy and up to one month after the discontinuation of the therapy? The way this sentence is currently worded is vague enough to cause significant confusion as to this restriction. Furthermore, none of the remaining sentences in the paragraph serve to elucidate the issue further, so I'm asking for someone with relevant knowledge to reword the sentence in such a way that eliminates this possible source of confusion.

Why are these sources removed?[edit]

Why are these sources I added removed? From MHRA at the UK government, and controlled studies. The findings are also consistent with other studies that show the same thing. If I also add the other studies showing the same thing, would you then please not remove them, @Kimen8 , but thanks for the edits of grammar.

24. "Review of isotretinoin and psychiatric adverse reactions" (PDF). Medicines and Healthcare products Regulatory Agency (MHRA). www.gov.uk. November 2014. Retrieved 2 April 2024.

26. Alamri A, Khafaji R, Balkhy A, Samarkandy S, Alraddadi A (December 2023). "The Psychological Impact of Isotretinoin Therapy on Acne Vulgaris Patients". Cureus. 15 (12): e50612. doi:10.7759/cureus.50612. PMC 10724700. PMID 38107219.

30. Saraç G, Koca TT, Şener S, Hakverdi G (15 March 2018). "Effect of 6-Month Isotretinoin Treatment on 25-Hydroxyvitamin D Levels in Patients With Acne Vulgaris". Journal of Clinical Medicine of Kazakhstan. 1 (47): 25–28. doi:10.23950/1812-2892-JCMK-00537. ISSN 1812-2892.

31. Gökalp H, Bulur I, Gürer M (2014). "Decreased vitamin B 12 and folic acid concentrations in acne patients after isotretinoin therapy: A controlled study". Indian Journal of Dermatology. 59 (6): 630. doi:10.4103/0019-5154.143533. ISSN 0019-5154. PMC 4248518. PMID 25484410. Tomsiti (talk) 13:02, 3 April 2024 (UTC)[reply]

Based on WP:MEDRS, I removed what I thought were WP:PRIMARY sources, including trials/intervention studies. Controlled studies are not to be used as a reference for your insertion, unless you happen to be saying that there exists such a study, perhaps to say that research on some topic is ongoing (i.e., do not use its results conclusively). Favor WP:SECONDARY sources, such literature reviews, meta-analyses, and the like. If you believe any of those do fit WP:MEDRS you are free to put them back. If you add good sources, of course I will not remove them (unless I do so by accident, in which case just WP:AGF and revert or let me know). Kimen8 (talk) 16:07, 3 April 2024 (UTC)[reply]