Talk:Domoic acid

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Is domoic acid responsible for most forms of ASP, or only some? Mentioning red tides suggests it is produced mainly by dinoflagellates, but information on the web links it mainly to diatoms.

Red tides and red algae are not synonymous. Red tides are so named for their visual appearance (reflectance) red algae are so named for their photochemistry (absorbance), these are opposite uses of the same adjective. —Preceding unsigned comment added by 198.123.41.42 (talk) 21:14, 4 August 2008 (UTC)[reply]

Response: Domoic acid is the phycotoxin responsible, specifically, for ASP (Amnesic Shellfish Poisoning); there is only one "form". It is produced by some diatoms and some red macroalgae, but not by any dinoflagellates (so far). The term "Harmful Algal Bloom" (HAB) has often replaced the more commonly known descriptor, "red tide".

AMPA and kainate are pharmacologic agents used to distinguish between different glutamate receptor subtypes. The physiologic neuotransmitter that they respond to is glutamate, AMPA and Kainate are not produced in the brain. For clarity, I would suggest referring to them as "glutamate receptors (AMPA/kainate subtype)".

It is "commercially available" for what purpose?

Comparing the structure of domoic acid shown on this page, there is no information on the configuration of the chiral center at the CH-COOH group (should be (R)), and also the first double bond in the side chain is shown as (E) - which is wrong - instead of (Z). see: [1]

-- Krakatit (talk) 15:53, 21 June 2008 (UTC)[reply]

I second the comments from Krakatit - the structure as shown on the article page is wrong/incomplete. The structure should be as given in the Aldrich link he provided and as confirmed in the STN databases (CAS# 14277-97-5). Name as given by STN/CAS for this substance with this Registry number, the L-form:

    3-Pyrrolidineacetic acid, 2-carboxy-4-[(1Z,3E,5R)-5-carboxy-1-methyl-1,3-hexadien-1-yl]-, (2S,3S,4S)-

and which is the substance referred to in the literature (1010 references in STN currently). As a new user I am unable to upload the corrected structure; perhaps an established user/editor could? (Chimia69 (talk) 17:50, 18 January 2009 (UTC))[reply]

The correct structure is shown here: http://www.chemspider.com/Chemical-Structure.4445428.html--ChemSpiderMan (talk) 03:23, 11 April 2009 (UTC)[reply]

I am retracting the comment about the structure above being the correct structure. I am seeing conflicting information now about E/Z orientation and am working to figure it out. --ChemSpiderMan (talk) 15:01, 14 April 2009 (UTC) All is well - everything is checked[reply]

I notice that the structure has been updated with stereochemistry for the side chain methyl. However, the E/Z stereo is still incorrect. I will update the structure this evening. --ChemSpiderMan (talk) 01:31, 15 April 2009 (UTC)[reply]

1/100th amount toxic to nerves is toxic to kidneys[edit]

Even at 1/100 the level toxic to nerves, demoic acid appears to be toxic to the kidneys.

"Posted: 07 Feb 2014 05:36 AM PST Domoic acid accumulates in seafood and is toxic to the brain. Research indicates that the toxin damages kidneys at concentrations that are 100 times lower than what causes neurological effects."

^[1] dcebr 13:24, 8 February 2014 (UTC)

References

^ http://www.sciencedaily.com/releases/2014/02/140206155248.htm

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Federal limit[edit]

The article says 20 mg / kg tissue, but that figure does not make any sense. The source says part per million, could someone change it? — Preceding unsigned comment added by 24.18.38.178 (talk) 02:26, 5 February 2018 (UTC)[reply]

Questionable History Section Addition[edit]

A news article came out and claimed seals are attacking people because of this chemical from algae blooms. I'm unsure if people think this source and speculation is worth adding.

Source JackW2 (talk) 05:16, 1 July 2023 (UTC)[reply]

[1] ttp://www.sciencedaily.com/releases/2014/02/140206155248.htm

[1]