Talk:Mastocytosis

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c-kit[edit]

c-kit mutations are common in SM] Imatinib, anyone? JFW | T@lk 06:58, 27 September 2006 (UTC)[reply]

PREVENTION[edit]

THERES TREATMENTS FOR THE SYMPTOMS BUT IS THERE PREVENTIONS FOR THE PROBLEM? LIKE EATING CERTAIN FOODS AND THE REST? —Preceding unsigned comment added by 24.188.17.249 (talk) 16:37, 16 May 2008 (UTC)[reply]

Insert non-formatted text here== HELP ==

Where the Mastocycoma is locaited on the arm of a child, can the arm of the child just stop working, go limp so to speak or have any pain do to this?

My son has this on his left arm today he stopped useing this arm, you can tell there is still feeling in his arm but he is not lifting things or raising his left arm.

So the question is, is this caused by the Mastocycoma on his arm?

Please Anwser Or write if you and you know some one that has this disorder. ms_princess_420@hotmail.com —Preceding unsigned comment added by 75.100.47.125 (talk) 23:26, 25 July 2008 (UTC)[reply]

Insert non-formatted text here== Lack of documentation to support promotion of antidepressant use by people with mastocytosis == 

 A point stated in the article:

"Antidepressants are an important and often overlooked tool in the treatment of mastocytosis. The

stress and physical discomfort of any chronic disease may increase the likelihood of a patient

developing depression. Depression and other neurological symptoms have been noted in

mastocytosis.[7] Some antidepressants such as doxepin are themselves potent antihistamines and can

help relieve physical as well as cognitive symptoms."






  We are a referred to an article [7].  The article only mentions antidepressants being used by

three of the people in the study reference.  There is nothing documenting efficacy although it

is

reported that one of three on an antidepressant attempted suicide.




 Given that it has been found that antidepressants are ineffective approximately 66% of the time,

and placebos effective 30% of the time, strong promotion (as above) of antidepressants in the

treatment of mastocytosis is inappropriate without documentation.  Further, there is no

documentation showing Doxepin as efficacious in treating "physical as well as cognitive symptoms".

Halaluani (talk) 06:18, 15 June 2010 (UTC)[reply]

Doxepin[edit]

Doxepin is an tricyclic antidepressant at 150mg or greater however at lower doses doxepin acts more as an antihistamine. Doxepin is a strong H1, H2 and H4 antihistamine. H1, H2 and H4 receptors are dominant on the human mast cell making doxepin something of a mast cell stabilizer. The trouble with using doxepin to treat systemic mastocytosis is people with this disease may have abnormal serotonin levels so even at a very low dose there is a risk of serotonin toxicity. Usually the benefits here outweigh the risk of trying doxepin as its effective against bone pain, neuropathic pain, dementia and flushing. I'm speaking from experience here as a patient however I will try to get you some references. Buddha443556 (talk) 16:32, 29 November 2010 (UTC)[reply]

Dementia[edit]

Two symptom that are missing from the mastocytosis page is dementia and delirium. Mastocytosis patients refer to it as brain fog. Realize the is one of the most disabling symptom of systemic mastocytosis if your thinking is impaired there is not much in the way of work you can do and you will be lucky to be able to care for yourself. See http://www.psychosomaticmedicine.org/cgi/reprint/48/6/437.pdf Buddha443556 (talk) 16:46, 29 November 2010 (UTC)[reply]

Proposed merge[edit]

Hello to all! I am proposing a merge from the following articles into this article:

This is for the following reasons:

  • These articles are very short in length (1-2 sentences) and have not been edited significantly in 3-4 years.
  • This knowledge shouldn't be obscured from readers of this article by virtue of being isolated in an obscure article of 1-2 lines.
  • These topics may receive more attention by being mentioned in the main article.
  • The articles, if needs be, could be re-expanded at a later date.

Kind Regards, LT90001 (talk) 13:21, 9 August 2013 (UTC)[reply]

Hello! I agree that articles on ICD-acknowledged forms of mastocytosis should be merged, i.e. types of mastocytosis with similar pathogenesis. Further I don't find it natural to merge articles on reactive forms of mastocytosis with other pathogenesis.

Kind regards, Carl Michael Berg (talk) 19:50, 15 September 2013 (UTC)[reply]

Critical care management[edit]

doi:10.1186/s13054-015-0956-z JFW | T@lk 09:01, 12 June 2015 (UTC)[reply]

NEJM[edit]

doi:10.1056/NEJMra1409760 JFW | T@lk 22:44, 8 July 2015 (UTC)[reply]

WHO 2016[edit]

Blood 2017 129:1420-1427; doi:10.1182/blood-2016-09-731893 JFW | T@lk 09:45, 17 March 2017 (UTC)[reply]

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darier's sign[edit]

I think there should be mention of Darier's sign, where when a lesion is scratched it creates a erythematous and pruritic response. — Preceding unsigned comment added by 2607:FEA8:3C20:111A:6D9D:99F:470A:77CA (talk) 18:28, 20 August 2018 (UTC)[reply]

Done --Jhoughton1 (talk) 18:08, 4 July 2020 (UTC)[reply]

Review[edit]

Br J Haem doi:10.1111/bjh.16288 JFW | T@lk 13:47, 4 February 2020 (UTC)[reply]

Another diagnosis?[edit]

Hmmmm. I came to this page because I have massive sun-exacerbated skin rash on my forearms, almost certainly caused as a side effect to my immunotherapy (Keytruder for metastatic ureterial cancer). My local doctor suspects possibly also mastocytosis, also from the immuno, and says that there is a specific blood test for it. THere is no mention of a blood test under Diagnosis that my non-knowledge of medicine can discern. — Preceding unsigned comment added by 2001:8003:E422:3C01:1D88:2285:7779:B2F9 (talk) 02:01, 29 January 2021 (UTC)[reply]

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